| Date and Venue Information: | |
| 12 September 2016 |
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| Title of Lecture: | |
| "Engineered Nanomaterials for Molecular Sensing and Bioimaging" by Edakkattuparambil S. Shibu, University of Bordeaux, France |
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| Abstract | |
| Nanomaterials have been emerged as potential candidates in biolabeling, bioimaging, molecular sensing, delivery and therapeutics. In the beginning of this talk, I shall present the fabrication of different luminescent nanomaterials, particularly gold quantum clusters (sub-nanoparticles). The inherent NIR-photoluminescence of these materials is efficiently used for different applications including metal ion sensing, development of luminescent patterns, fabrication of self-erasing inks and bioimaging. Later on, development of bimodal nanoparticles bridged with quantum dots and iron oxide nanoparticles via a novel photolabile coumarin bis-biotin molecules, their receptor medicated intracellular delivery, fluorescence and magnetic resonance based-bimodal imaging both in vitro and in vivo, and bio-distribution studies will be described. The toxicity issues of quantum dots in the bimodal nanoparticles will be addressed by choosing non-toxic, NIR-emitting gold quantum clusters. Following, the remedy for intrinsic blinking of quantum dots at single-particle level will be discussed. Scope of new imaging technique, photothermal optical microscopy and its suitable nano-probes will be explained. The above-mentioned engineered nanomaterials having exceptional chemical/photostability and intense luminescence/plasmonic absorption offers many applications in biology. Some of these applications are described, especially in the context of biolabeling and bioimaging at single-particle level. For details please click here. |
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