IIT Jodhpur
Sushanta Kumar Parida, Sudhir Kumar Hota and Sandip Murarka's recent contribution in the field of N-(acylox) phthalimides as redox-active esters is published in the journal 'ACS Catalysis' (Impact Factor: 12.35)

The last decade has witnessed the emergence of N-(acyloxy)phthalimides (NHPI esters) and its derivatives at the forefront of synthetic methods facilitating the construction of diverse molecular frameworks from the readily available carboxylic acid feedstock. The NHPI esters are predisposed to undergo reductive fragmentation via a single electron transfer (SET) process under thermal, photochemical or electrochemical conditions to generate the corresponding carbon- or nitrogen-centered radicals that participate in a multitude of synthetic transformations to forge carbon-carbon and carbon-heteroatom bonds. The chemistry involving NHPI esters has received broad applicability not only in well-designed cascade annulations but also in medicinal chemistry and natural product synthesis. The comprehensive review, broadly categorized according to the nature of the bond formation, details the progress made in this field since the initial discovery by providing representative examples with mechanistic details with an emphasis on challenges and future directions.


More about the article can be found here:

Sushanta Kumar Parida, Tanumoy Mandal, Sanju Das, Sudhir Kumar Hota, Suman De Sarkar*, and SandipMurarka*, Single Electron Transfer-Induced Redox Processes Involving N-(Acyloxy)phthalimides, ACS Catal. 2021, 11, 1640–1683. [Link]