Title: BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis,
Journal: Molecular Cell
Brief overview:
Microtubule binding to kinetochores, a multisubunit protein complex on chromosomes, involves complex regulatory networks of confined mitotic kinases, their substrates and counteracting proteins as phosphates. The research work utilizes a combination of ectopic targeting, in
vitro recombination and kinetochore localization tools to provide a unifying mechanistic model of mitotic kinase PLK1 localization at human kinetochores.
Full article:
https://www.cell.com/molecular
